[Submitted on 16 Oct 2023]

Download PDF

Abstract:Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $Nsim 100$ neurons. As $N$ increases in new experiments, we enter an undersampled regime where we have to choose which observables should be constrained in the maximum entropy construction. The best choice is the one that provides the greatest reduction in entropy, defining a “minimax entropy” principle. This principle becomes tractable if we restrict attention to correlations among pairs of neurons that link together into a tree; we can find the best tree efficiently, and the underlying statistical physics models are exactly solved. We use this approach to analyze experiments on $Nsim 1500$ neurons in the mouse hippocampus, and show that the resulting model captures the distribution of synchronous activity in the network.

Submission history

From: Christopher Lynn [view email]

[v1]
Mon, 16 Oct 2023 22:21:53 UTC (3,071 KB)

Read More